SLU PP 332

SLU PP 332 is a synthetic small-molecule agonist of the estrogen-related receptors ERRα and ERRγ — orphan nuclear receptors that act as master regulators of mitochondrial biogenesis and oxidative metabolism. It has been studied as a potential exercise mimetic capable of activating metabolic gene programs without physical activity.

Research has investigated SLU PP 332 for its ability to upregulate PGC-1α target genes, increase mitochondrial density, and improve oxidative capacity in muscle tissue in preclinical models. This positions it as a novel research tool for studying metabolic disease, age-related muscle decline, and the molecular basis of exercise adaptation.