CJC-1295 (No DAC)

CJC-1295 (No DAC) is a synthetic analogue of growth hormone-releasing hormone (GHRH) without the drug affinity complex (DAC) modification. The absence of DAC gives it a shorter half-life relative to the DAC version, producing more physiologically pulsatile GH release patterns that more closely mirror natural secretion.

Research has investigated CJC-1295 (No DAC) for its ability to amplify GH pulse amplitude when co-administered with GH secretagogues such as Ipamorelin. It is one of the most widely studied GHRH analogues in peptide research, with applications in GH axis regulation, body composition, and recovery models.