5-Amino-1-MQ

5-Amino-1-methylquinolinium (5-Amino-1-MQ) is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that plays a central regulatory role in cellular energy metabolism and adipogenic differentiation.

Research has investigated 5-Amino-1-MQ for its ability to suppress fat cell differentiation (adipogenesis), increase energy expenditure, and improve markers of metabolic health in preclinical models. By inhibiting NNMT, it may shift NAD+ and SAM metabolic flux in ways that alter epigenetic programming in adipose tissue, making it a novel research tool for studying the molecular basis of obesity and metabolic syndrome.